Problems with notification emails

Problems with notification emails

We have setup a number of message rules that should send e-mails when certain things occur. Since yesterday some of these notification e-mails are not sent (or delivered) to the client. For example, when end users create a new case, sometimes they don't get the confirmation e-mail with the case #. 

After restarting the services it seems to work for a while.

Any ideas how to start troubleshoot this?

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